Reaction Details Report a problem with these data
Target
Gastric inhibitory polypeptide receptor
Ligand
BDBM50360599
Substrate
n/a
Meas. Tech.
ChEMBL_795449 (CHEMBL1937454)
Ki
927±n/a nM
Citation
 Filipski, KJ; Bian, J; Ebner, DC; Lee, EC; Li, JC; Sammons, MF; Wright, SW; Stevens, BD; Didiuk, MT; Tu, M; Perreault, C; Brown, J; Atkinson, K; Tan, B; Salatto, CT; Litchfield, J; Pfefferkorn, JA; Guzman-Perez, A A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity. Bioorg Med Chem Lett 22:415-20 (2011) [PubMed]  Article 
Target
Name:
Gastric inhibitory polypeptide receptor
Synonyms:
GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor
Type:
PROTEIN
Mol. Mass.:
53173.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1518286
Residue:
466
Sequence:
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
  
Inhibitor
Name:
BDBM50360599
Synonyms:
CHEMBL1933365
Type:
Small organic molecule
Emp. Form.:
C26H27F3N4O3
Mol. Mass.:
500.5128
SMILES:
OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)C1CCCC1
Structure:
Search PDB for entries with ligand similarity: