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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50361443
Substrate
n/a
Meas. Tech.
ChEMBL_794579 (CHEMBL1936998)
Ki
5000±n/a nM
Citation
 Kremerovñ, M; Dracínský, M; Hocková, D; Holý, A; Keough, DT; Guddat, LW Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorg Med Chem 20:1222-30 (2012) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50361443
Synonyms:
CHEMBL1934409
Type:
Small organic molecule
Emp. Form.:
C11H16N5O8P
Mol. Mass.:
377.2472
SMILES:
Nc1nc2n(CC(COCP(O)(O)=O)OCC(O)=O)cnc2c(=O)[nH]1
Structure:
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