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TargetBradykinin B1 receptor
LigandBDBM50362319
Substrate/Competitorn/a
Meas. Tech.ChEMBL_797692
IC50 23.4±n/a nM
Citation Qian, WChen, JJHuman, JAya, TZhu, JBiswas, KPeterkin, THungate, RWArik, LJohnson, EKumar, GJoseph, SJona, JGuo, HXWu, Z Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency. Bioorg Med Chem Lett22:1061-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50362319
NameBDBM50362319
Synonyms:CHEMBL1939950
TypeSmall organic molecule
Emp. Form.C24H33ClN4O4S
Mol. Mass.509.061
SMILESCc1cc(c(C)cc1Cl)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N1CCCC[C@@H](C1)N1CCCC1 |r,c:14|
Structure
n/a