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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50363937
Substrate
n/a
Meas. Tech.
ChEMBL_802535 (CHEMBL1952571)
EC50
1.8±n/a nM
Citation
 Nishi, T; Miyazaki, S; Takemoto, T; Suzuki, K; Iio, Y; Nakajima, K; Ohnuki, T; Kawase, Y; Nara, F; Inaba, S; Izumi, T; Yuita, H; Oshima, K; Doi, H; Inoue, R; Tomisato, W; Kagari, T; Shimozato, T Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist. ACS Med Chem Lett 2:368-372 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CD_antigen=CD363 | Edg1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor 1 | S1P receptor Edg-1 | S1P1 | S1PR1_RAT | S1pr1 | Sphingosine 1-phosphate receptor Edg-1
Type:
PROTEIN
Mol. Mass.:
42770.88
Organism:
Rattus norvegicus
Description:
ChEMBL_1463793
Residue:
383
Sequence:
MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50363937
Synonyms:
CHEMBL1951588
Type:
Small organic molecule
Emp. Form.:
C21H31N2O5P
Mol. Mass.:
422.455
SMILES:
Cc1ccc(CCCC(=O)c2ccc(CC[C@@](C)(N)COP(O)(O)=O)n2C)cc1 |r|
Structure:
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