Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50026836
Substrate
n/a
Meas. Tech.
ChEMBL_807302 (CHEMBL1960395)
IC50
1995±n/a nM
Citation
 Gentile, G; Merlo, G; Pozzan, A; Bernasconi, G; Bax, B; Bamborough, P; Bridges, A; Carter, P; Neu, M; Yao, G; Brough, C; Cutler, G; Coffin, A; Belyanskaya, S 5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors. Bioorg Med Chem Lett 22:1989-94 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50026836
Synonyms:
CHEMBL1957227
Type:
Small organic molecule
Emp. Form.:
C18H13ClF3N3O3
Mol. Mass.:
411.762
SMILES:
COc1ccc(cc1Cl)-c1ocnc1C(=O)NCc1ccnc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: