Reaction Details
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Ligand
BDBM50110681
Substrate
n/a
Meas. Tech.
ChEBML_161424
IC50
0.130000±n/a nM
Citation
Quinn, RJ; Taylor, C; Suganuma, M; Fujiki, H The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects. Bioorg Med Chem Lett 3:1029-1034 (1993) Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Synonyms:
2A5A_HUMAN | PPP2R5A | Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Type:
PROTEIN
Mol. Mass.:
56194.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161424
Residue:
486
Sequence:
MSSSSPPAGAASAAISASEKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLKDATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSILSNTSAE
Inhibitor
Name:
BDBM50110681
Synonyms:
CHEMBL430266 | Calyculin-A
Type:
Small organic molecule
Emp. Form.:
C50H81N4O15P
Mol. Mass.:
1009.1697
SMILES:
COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C |r|
Structure:
