Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50449912
Substrate
n/a
Meas. Tech.
ChEMBL_34833 (CHEMBL648767)
Ki
8.9±n/a nM
Citation
 Poss, MA; Gu, Z; Ryono, DE; Reid, JA; Sieber-McMaster, E; Spitzmiller, ER; Dejneka, T; Dickinson, KE; Williams, SB; Moreland, S; Delaney, CL; Bird, J; Waldron, TL; Schaeffer, TR; Hedberg, S; Petrillo, EW 1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists Bioorg Med Chem Lett 4:145-150 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50449912
Synonyms:
CHEMBL2079781
Type:
Small organic molecule
Emp. Form.:
C33H37ClKN7O4
Mol. Mass.:
670.243
SMILES:
[K+].CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2n(ccc12)-c1ccccc1-c1nn[n-]n1
Structure:
Search PDB for entries with ligand similarity: