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Target
Glutamate--cysteine ligase catalytic subunit
Ligand
BDBM50366432
Substrate
n/a
Meas. Tech.
ChEMBL_68754 (CHEMBL681831)
Ki
390±n/a nM
Citation
 Katoh, M; Hiratake, J; Kato, H; Oda, J Mechanism-based inactivation of E. coli -glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues Bioorg Med Chem Lett 6:1437-1442 (1996)    Article 
Target
Name:
Glutamate--cysteine ligase catalytic subunit
Synonyms:
GCLC | GLCL | GLCLC | GSH1_HUMAN | Gamma-glutamylcysteine synthetase
Type:
PROTEIN
Mol. Mass.:
72759.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68753
Residue:
637
Sequence:
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
  
Inhibitor
Name:
BDBM50366432
Synonyms:
CHEMBL1627263
Type:
Small organic molecule
Emp. Form.:
C9H16N2O5S
Mol. Mass.:
264.299
SMILES:
CCC(CS(=N)(=O)CCC(=N)C(O)=O)C(O)=O
Structure:
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