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Target
Endothelin-1 receptor
Ligand
BDBM50287881
Substrate
n/a
Meas. Tech.
ChEBML_65818
Ki
>10000±n/a nM
Citation
 Fruh, T; Saika, H; Svensson, L; Pitterna, T; Sakaki, J; Okada, T; Urade, Y; Oda, K; Fujitani, Y; Takimoto, M; Yamamura, T; Inui, T; Makatani, M; Umemura, I; Teno, N; Toh, H; Hayakawa, K; Murata, T IRL 2500: A potent ETB selective endothelin antagonist Bioorg Med Chem Lett 6:2323-2328 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_PIG | Endothelin receptor ET-A
Type:
PROTEIN
Mol. Mass.:
48707.29
Organism:
Sus scrofa
Description:
ChEMBL_65803
Residue:
427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50287881
Synonyms:
CHEMBL216772 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-lle-lle-Gly-COOH
Type:
Small organic molecule
Emp. Form.:
C68H98N14O21
Mol. Mass.:
1447.5869
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)CCC(O)=O)C(C)C)[C@@H](C)CC)C(=O)NCC(O)=O
Structure:
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