Reaction Details Report a problem with these data
Target
Gastrin-releasing peptide receptor
Ligand
BDBM50288252
Substrate
n/a
Meas. Tech.
ChEBML_71531
Ki
0.700000±n/a nM
Citation
 Eden, J; Hall, M; Higginbottom, M; Horwell, D; Howson, W; Hughes, J; Jordan, R; Lewthwaite, R; Martin, K; McKnight, A; Pinnock, R; Pritchard, M; Suman-Chauhan, N; Williams, S PD 165929 the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist Bioorg Med Chem Lett 6:2617-2622 (1996)    Article 
Target
Name:
Gastrin-releasing peptide receptor
Synonyms:
Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43214.53
Organism:
Homo sapiens (Human)
Description:
Bombesin 2 GRPR 0::P30550
Residue:
384
Sequence:
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
  
Inhibitor
Name:
BDBM50288252
Synonyms:
Bombesin analogue | CHEMBL269432
Type:
Small organic molecule
Emp. Form.:
C51H72N10O12
Mol. Mass.:
1017.1772
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(O)=O
Structure:
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