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Target
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Ligand
BDBM50090505
Substrate
n/a
Meas. Tech.
ChEBML_161425
IC50
8000±n/a nM
Citation
 McCluskey, A; Taylor, C; Quinn, RJ; Suganuma, M; Fujiki, H Inhibition of protein phosphatase 2A by cantharidin analogues Bioorg Med Chem Lett 6:1025-1028 (1996)    Article 
Target
Name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms:
2AAA_MOUSE | Ppp2r1a | Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
Type:
PROTEIN
Mol. Mass.:
65303.23
Organism:
Mus musculus
Description:
ChEMBL_161425
Residue:
589
Sequence:
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
  
Inhibitor
Name:
BDBM50090505
Synonyms:
(1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione | CANTHARIDIN | CHEMBL48449 | cid_6708701
Type:
Small organic molecule
Emp. Form.:
C10H12O4
Mol. Mass.:
196.1999
SMILES:
C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Structure:
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