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Target
72 kDa type IV collagenase
Ligand
BDBM50078568
Substrate
n/a
Meas. Tech.
ChEBML_101933
IC50
4.1±n/a nM
Citation
 Hanessian, S; Bouzbouz, S; Boudon, A; Tucker, GC; Peyroulan, D Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett 9:1691-6 (1999) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | Gelatinase A | MMP-2 | MMP2_MOUSE | Matrix metalloproteinase-2 | Mmp2
Type:
PROTEIN
Mol. Mass.:
74091.47
Organism:
Mus musculus
Description:
ChEMBL_101933
Residue:
662
Sequence:
MEARVAWGALAGPLRVLCVLCCLLGRAIAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRNDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50078568
Synonyms:
(S)-4-Benzylsulfanyl-2-[(biphenyl-4-sulfonyl)-isobutyl-amino]-N-hydroxy-butyramide | CHEMBL47414
Type:
Small organic molecule
Emp. Form.:
C27H32N2O4S2
Mol. Mass.:
512.684
SMILES:
CC(C)CN([C@@H](CCSCc1ccccc1)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: