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TargetGrowth factor receptor-bound protein 2
LigandBDBM50089528
Substrate/Competitorn/a
Meas. Tech.ChEBML_72352
IC50 5000±n/a nM
Citation Kim, HKNam, JYHan, MYSon, KHChoi, JDKwon, BMTakusagawa, HLHuang, YTakusagawa, F Natural and synthetic analogues of actinomycin D as Grb2-SH2 domain blockers. Bioorg Med Chem Lett10:1455-7 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth factor receptor-bound protein 2
Name:Growth factor receptor-bound protein 2
Synonyms:Adapter protein GRB2 | SH2/SH3 adapter GRB2
Type:PROTEIN
Mol. Mass.:25237.10
Organism:Mus musculus
Description:ChEMBL_72352
Residue:217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50089528
NameBDBM50089528
Synonyms:Actinomycin D | Actinomycin D analogue | Cosmegen | DACTINOMYCIN | Dactinomycin
TypeSmall organic molecule
Emp. Form.C62H86N12O16
Mol. Mass.1255.417
SMILES[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r|
Structure
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