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Target
Protein phosphatase 1B
Ligand
BDBM50090509
Substrate
n/a
Meas. Tech.
ChEBML_161763
IC50
2960±n/a nM
Citation
 McCluskey, A; Bowyer, MC; Collins, E; Sim ATR, na; Sakoff, JA; Baldwin, ML Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity. Bioorg Med Chem Lett 10:1687-90 (2000) [PubMed]  Article 
Target
Name:
Protein phosphatase 1B
Synonyms:
PP2C-beta | PP2CB | PPM1B | PPM1B_HUMAN | Protein phosphatase 1B | Protein phosphatase 2C beta | Protein phosphatase 2C isoform beta
Type:
PROTEIN
Mol. Mass.:
52620.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161756
Residue:
479
Sequence:
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
  
Inhibitor
Name:
BDBM50090509
Synonyms:
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl ester | (1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl ester | CHEMBL48076
Type:
Small organic molecule
Emp. Form.:
C10H14O5
Mol. Mass.:
214.2152
SMILES:
CCOC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Structure:
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