Reaction Details
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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Ligand
BDBM50090505
Substrate
n/a
Meas. Tech.
ChEBML_161773
IC50
260±n/a nM
Citation
McCluskey, A; Bowyer, MC; Collins, E; Sim ATR, na; Sakoff, JA; Baldwin, ML Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity. Bioorg Med Chem Lett 10:1687-90 (2000) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Synonyms:
Serine-threonine protein phosphatase 2A regulatory subunit
Type:
PROTEIN
Mol. Mass.:
49694.81
Organism:
Gallus gallus
Description:
ChEMBL_161937
Residue:
426
Sequence:
DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYIFQDKMN
Inhibitor
Name:
BDBM50090505
Synonyms:
(1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione | CANTHARIDIN | CHEMBL48449 | cid_6708701
Type:
Small organic molecule
Emp. Form.:
C10H12O4
Mol. Mass.:
196.1999
SMILES:
C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Structure:
