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Target
Kappa-type opioid receptor
Ligand
BDBM50085025
Substrate
n/a
Meas. Tech.
ChEBML_146512
Ki
410±n/a nM
Citation
 Wentland, MP; Xu, G; Cioffi, CL; Ye, Y; Duan, W; Cohen, DJ; Colasurdo, AM; Bidlack, JM 8-Aminocyclazocine analogues: synthesis and structure-activity relationships. Bioorg Med Chem Lett 10:183-7 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50085025
Synonyms:
(6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-pyrrolidin-1-yl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine | 3-Cyclopropylmethyl-6,11-dimethyl-8-pyrrolidin-1-yl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine | CHEMBL55948
Type:
Small organic molecule
Emp. Form.:
C22H32N2
Mol. Mass.:
324.5029
SMILES:
C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCCC1 |TLB:8:9:1:14.12.13,15:14:1:9.4.3|
Structure:
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