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Target
Vacuolar proton pump subunit B
Ligand
BDBM50064186
Substrate
n/a
Meas. Tech.
ChEMBL_148285 (CHEMBL750200)
IC50
30±n/a nM
Citation
 Edvinsson, KM; Herslöf, M; Holm, P; Kann, N; Keeling, DJ; Mattsson, JP; Nordén, B; Shcherbukhin, V Solid phase synthesis of diamides as potential bone resorption inhibitors. Bioorg Med Chem Lett 10:503-7 (2000) [PubMed]  Article 
Target
Name:
Vacuolar proton pump subunit B
Synonyms:
Adenosinetriphosphatase | Uncharacterized protein | Vacuolar H-ATPase B subunit osteoclast isozyme
Type:
PROTEIN
Mol. Mass.:
55043.78
Organism:
Gallus gallus
Description:
ChEMBL_148284
Residue:
496
Sequence:
RRMVNGAGPGGAREQAAALTRDFLSQPRLTYKTVSGVNGPLVILDQVKFPRYAEIVHLTLPDGTRRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPAVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVMDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQTTLAEFYPRDSTAKH
  
Inhibitor
Name:
BDBM50064186
Synonyms:
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one | CHEMBL290814 | bafilomycin A1
Type:
Small organic molecule
Emp. Form.:
C35H58O9
Mol. Mass.:
622.8296
SMILES:
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C |c:5,15,18,t:3|
Structure:
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