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Target
Deoxynucleoside kinase
Ligand
BDBM50132291
Substrate
n/a
Meas. Tech.
ChEBML_53736
IC50
65000±n/a nM
Citation
 Manfredini, S; Baraldi, PG; Durini, E; Porcu, L; Angusti, A; Vertuani, S; Solaroli, N; De Clercq, E; Karlsson, A; Balzarini, J Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. Bioorg Med Chem Lett 11:1329-32 (2001) [PubMed]  Article 
Target
Name:
Deoxynucleoside kinase
Synonyms:
DNK_DROME | Deoxyribonucleoside kinase | Dm-dNK | Multispecific deoxynucleoside kinase | dnk
Type:
PROTEIN
Mol. Mass.:
29092.93
Organism:
Drosophila melanogaster
Description:
ChEMBL_627484
Residue:
250
Sequence:
MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLVSPSKRQRVAR
  
Inhibitor
Name:
BDBM50132291
Synonyms:
1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 1-((2R,3S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 1-(beta-D-arabinofuranosyl)thymine | 1-beta-D-arabinofuranosylthymine | CHEMBL103283
Type:
Small organic molecule
Emp. Form.:
C10H14N2O6
Mol. Mass.:
258.228
SMILES:
Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]c1=O |r|
Structure:
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