Reaction Details Report a problem with these data
Target
Sodium-dependent dopamine transporter
Ligand
BDBM50102934
Substrate
n/a
Meas. Tech.
ChEBML_62502
Ki
>3000±n/a nM
Citation
 Petukhov, PA; Zhang, M; Johnson, KJ; Tella, SR; Kozikowski, AP Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. Bioorg Med Chem Lett 11:2079-83 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50102934
Synonyms:
(3S,4R)-4-(4-Chloro-phenyl)-3-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-piperidine | CHEMBL63196
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O2
Mol. Mass.:
383.871
SMILES:
COc1ccc(cc1)-c1noc(n1)[C@@H]1CN(C)CC[C@H]1c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: