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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50102941
Substrate
n/a
Meas. Tech.
ChEMBL_201992 (CHEMBL809437)
Ki
>3000±n/a nM
Citation
 Petukhov, PA; Zhang, M; Johnson, KJ; Tella, SR; Kozikowski, AP Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. Bioorg Med Chem Lett 11:2079-83 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50102941
Synonyms:
(3R,4S)-4-(4-Chloro-phenyl)-3-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-piperidine | CHEMBL292803
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O2
Mol. Mass.:
383.871
SMILES:
COc1ccc(cc1)-c1noc(n1)[C@H]1CN(C)CC[C@@H]1c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: