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Target
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Ligand
BDBM50090502
Substrate
n/a
Meas. Tech.
ChEMBL_161775 (CHEMBL768149)
IC50
410±n/a nM
Citation
 McCluskey, A; Walkom, C; Bowyer, MC; Ackland, SP; Gardiner, E; Sakoff, JA Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A. Bioorg Med Chem Lett 11:2941-6 (2001) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Synonyms:
Serine-threonine protein phosphatase 2A regulatory subunit
Type:
PROTEIN
Mol. Mass.:
49694.81
Organism:
Gallus gallus
Description:
ChEMBL_161937
Residue:
426
Sequence:
DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYIFQDKMN
  
Inhibitor
Name:
BDBM50090502
Synonyms:
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl ester | (1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl ester | CHEMBL47665
Type:
Small organic molecule
Emp. Form.:
C9H12O5
Mol. Mass.:
200.1886
SMILES:
COC(=O)C1[C@H]2CC[C@H](O2)C1C(O)=O
Structure:
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