Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50097737
Substrate
n/a
Meas. Tech.
ChEBML_40436
IC50
>100000±n/a nM
Citation
 Dziadulewicz, EK; Walpole, CS; Snell, CR; Wrigglesworth, R; Hughes, GA; Beattie, D; Wood, JN; Beech, MM; Coote, PR Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold. Bioorg Med Chem Lett 11:705-9 (2001) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BK-2 receptor | BKRB2_RAT | Bdkrb2 | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44941.22
Organism:
RAT
Description:
B2 BRADYKININ BDKRB2 RAT::P25023
Residue:
396
Sequence:
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
  
Inhibitor
Name:
BDBM50097737
Synonyms:
1-(2-nitrophenyl)thiosemicarbazide analogue | CHEMBL423803
Type:
Small organic molecule
Emp. Form.:
C24H22N6O6S2
Mol. Mass.:
554.598
SMILES:
OC(=O)c1cccc(NC(=[SH+])[N-]Nc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NCCc2c[nH]c3ccccc23)c1
Structure:
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