Reaction Details
Report a problem with these data
Report a problem with these dataTarget
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Ligand
BDBM50366832
Substrate
n/a
Meas. Tech.
ChEMBL_216151 (CHEMBL817034)
Ki
900000±n/a nM
Citation
Whalen, LJ; McEvoy, KA; Halcomb, RL Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases. Bioorg Med Chem Lett 13:301-4 (2002) [PubMed] Article More Info.:
Target
Name:
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Synonyms:
SIAT6_RAT | Siat6 | St3gal3
Type:
PROTEIN
Mol. Mass.:
42091.50
Organism:
Rattus norvegicus
Description:
ChEMBL_649270
Residue:
374
Sequence:
MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEDSNSLILSLDSAGQTLGTEYDRLGFLLKLDSKLPAELATKYANFSEGACKPGYASAMMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALDGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI
Inhibitor
Name:
BDBM50366832
Synonyms:
CHEMBL609516
Type:
Small organic molecule
Emp. Form.:
C15H25N4O9P
Mol. Mass.:
436.3542
SMILES:
CC(C)C[C@H](NP(O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1ccc(N)nc1=O)C(O)=O |r|
Structure:
