Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50127377
Substrate
n/a
Meas. Tech.
ChEBML_161790
IC50
500±n/a nM
Citation
 Liu, W; Sheppeck, JE; Colby, DA; Huang, HB; Nairn, AC; Chamberlin, AR The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity. Bioorg Med Chem Lett 13:1597-600 (2003) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
5.2.1.8 | PPP2R4 | PTPA | PTPA_HUMAN | Phosphotyrosyl phosphatase activator | Protein phosphatase 2A regulatory subunit B | Protein phosphatase 2A regulatory subunit B' | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4
Type:
n/a
Mol. Mass.:
40662.53
Organism:
Homo sapiens (Human)
Description:
Q15257
Residue:
358
Sequence:
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50127377
Synonyms:
10-[3,9-dimethyl-8-(3-methyl-4-oxopentyl)-(9R)-1,7-dioxaspiro[5.5]undec-2-yl]-3,7-dihydroxy-1-isopropyl-2-methoxy-6-methyl-5-oxoundecyl 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-3-furanyl)propanoate | CHEMBL40248
Type:
Small organic molecule
Emp. Form.:
C41H66O13
Mol. Mass.:
766.9549
SMILES:
CO[C@@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)[C@@H]1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(C)=O)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@H](O)C1=C(C)C(=O)OC1=O)C(C)C |c:45|
Structure:
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