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TargetVasopressin receptor
LigandBDBM50146290
Substrate/Competitorn/a
Meas. Tech.ChEMBL_214261
Ki 60±n/a nM
Citation Matthews, JMHoekstra, WJDyatkin, ABHecker, LRHlasta, DJPoulter, BLAndrade-Gordon, Pde Garavilla, LDemarest, KTEricson, EGunnet, JWHageman, WLook, RMoore, JBReynolds, CHMaryanoff, BE Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates. Bioorg Med Chem Lett14:2747-52 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin receptor
Name:Vasopressin receptor
Synonyms:AVPR V2 | AVPR2 | Antidiuretic hormone receptor | Renal-type arginine vasopressin receptor | VASOPRESSIN V2 | Vasopressin V2 receptor
Type:Receptor
Mol. Mass.:40295.28
Organism:Homo sapiens (Human)
Description:P30518
Residue:371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50146290
NameBDBM50146290
Synonyms:CHEMBL330494 | N-[3-Chloro-4-(3,4,11,11a-tetrahydro-1H,5H-2-thia-4a,10-diaza-dibenzo[a,d]cycloheptene-10-carbonyl)-phenyl]-5-fluoro-2-methyl-benzamide
TypeSmall organic molecule
Emp. Form.C27H25ClFN3O2S
Mol. Mass.510.023
SMILESCc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3CSCCN3Cc3ccccc23)c(Cl)c1
Structure
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n/a