Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50366914
Substrate
n/a
Meas. Tech.
ChEBML_214405
IC50
4±n/a nM
Citation
 Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Rybczynski, PJ; Patel, M Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists. Bioorg Med Chem Lett 14:3143-6 (2004) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50366914
Synonyms:
CHEMBL1788221
Type:
Small organic molecule
Emp. Form.:
C33H35FN4O3
Mol. Mass.:
554.6544
SMILES:
CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 |r,t:8|
Structure:
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