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Target
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Ligand
BDBM50366917
Substrate
n/a
Meas. Tech.
ChEMBL_69261 (CHEMBL677079)
IC50
3338±n/a nM
Citation
 Bryan, MC; Lee, LV; Wong, CH High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays. Bioorg Med Chem Lett 14:3185-8 (2004) [PubMed]  Article 
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Synonyms:
Alpha-(1,3)-fucosyltransferase IV | FCT3A | FUT6 | FUT6_HUMAN | Fucosyltransferase 6 | Fucosyltransferase IV | Fuct IV
Type:
n/a
Mol. Mass.:
41871.43
Organism:
Homo sapiens (Human)
Description:
P51993
Residue:
359
Sequence:
MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT
  
Inhibitor
Name:
BDBM50366917
Synonyms:
CHEMBL611881
Type:
Small organic molecule
Emp. Form.:
C27H31N9O12P2
Mol. Mass.:
735.5357
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](COP(O)(=O)OP(O)(=O)OCc2cn(CCC(=O)NCc3cccc4ccccc34)nn2)[C@@H](O)[C@H]1O |r|
Structure:
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