Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50028782
Substrate
n/a
Meas. Tech.
ChEBML_152417
IC50
454000±n/a nM
Citation
 Davis, DP; Borchardt, RT; Grunewald, GL Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of pi-electronic and steric interactions. J Med Chem 24:12-6 (1981) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50028782
Synonyms:
(endo)2-Amino-1-bicyclo[2.2.1]hept-5-en-2-yl-ethanol: Sulfate | 2-Amino-1-bicyclo[2.2.1]hept-5-en-2-yl-ethanol: Sulfate | CHEMBL40209
Type:
Small organic molecule
Emp. Form.:
C9H15NO
Mol. Mass.:
153.2215
SMILES:
NCC(O)C1CC2CC1C=C2 |c:10,TLB:2:4:9.10:7|
Structure:
Search PDB for entries with ligand similarity: