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Target
Angiotensin-converting enzyme 2
Ligand
BDBM50367255
Substrate
n/a
Meas. Tech.
ChEBML_35979
Ki
>150000±n/a nM
Citation
 Elliott, RL; Marks, N; Berg, MJ; Portoghese, PS Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme. J Med Chem 28:1208-16 (1985) [PubMed]  Article 
Target
Name:
Angiotensin-converting enzyme 2
Synonyms:
ACE2_RAT | Ace2 | Angiotensin-converting enzyme-related carboxypeptidase
Type:
PROTEIN
Mol. Mass.:
92475.04
Organism:
Rattus norvegicus
Description:
ChEMBL_35979
Residue:
805
Sequence:
MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENAQKMNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLTEPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISLKSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFNFFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVTIWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF
  
Inhibitor
Name:
BDBM50367255
Synonyms:
CHEMBL1744144
Type:
Small organic molecule
Emp. Form.:
C18H29N3O5PS
Mol. Mass.:
430.479
SMILES:
CCOP(=O)(CNC(C)=O)NC(Cc1ccccc1)NC(CCSC)C([O-])=O
Structure:
Search PDB for entries with ligand similarity: