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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024837
Substrate
n/a
Meas. Tech.
ChEBML_153309
Ki
>2000000±n/a nM
Citation
 Sall, DJ; Grunewald, GL Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site. J Med Chem 30:2208-16 (1988) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024837
Synonyms:
5-Methoxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine | CHEMBL70397
Type:
Small organic molecule
Emp. Form.:
C12H15NO
Mol. Mass.:
189.2536
SMILES:
COc1cccc2C3CC(C[C@H]3N)c12 |TLB:2:13:8:11.10,12:11:6.13:8,5:6:8:11.10|
Structure:
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