Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM50367487
Substrate
n/a
Meas. Tech.
ChEMBL_207848 (CHEMBL810057)
Ki
1400±n/a nM
Citation
 Mansuri, MM; Ghazzouli, I; Chen, MS; Howell, HG; Brodfuehrer, PR; Benigni, DA; Martin, JC 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem 30:867-71 (1987) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50367487
Synonyms:
CHEMBL475717
Type:
Small organic molecule
Emp. Form.:
C10H13FN2O5
Mol. Mass.:
260.219
SMILES:
Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)c(=O)[nH]c1=O |r|
Structure:
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