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Target
Aromatase
Ligand
BDBM50024484
Substrate
n/a
Meas. Tech.
ChEBML_51214
EC50
>2000±n/a nM
Citation
 Taylor, HM; Jones, CD; Davenport, JD; Hirsch, KS; Kress, TJ; Weaver, D Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. J Med Chem 30:1359-65 (1987) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50024484
Synonyms:
5-[1,1,2-Tris-(4-chloro-phenyl)-ethyl]-pyrimidine | CHEMBL29514
Type:
Small organic molecule
Emp. Form.:
C24H17Cl3N2
Mol. Mass.:
439.764
SMILES:
Clc1ccc(CC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)c2cncnc2)cc1
Structure:
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