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TargetCytochrome P450 19A1
LigandBDBM50014815
Substrate/Competitorn/a
Meas. Tech.ChEBML_51214
EC50 71±n/a nM
Citation Taylor, HMJones, CDDavenport, JDHirsch, KSKress, TJWeaver, D Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. J Med Chem30:1359-65 (1987) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 19A1
Name:Cytochrome P450 19A1
Synonyms:Aromatase | CYPXIX | Estrogen synthetase | P-450AROM
Type:PROTEIN
Mol. Mass.:58418.09
Organism:Rattus norvegicus
Description:ChEMBL_51211
Residue:508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLI
SHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKR
GLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD
NSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWL
YRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCI
LEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFI
NESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEK
NVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLH
LDEDSPIVEIIFRHIFNTPFLQCLYISL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50014815
NameBDBM50014815
Synonyms:Bis-(4-chloro-phenyl)-pyrimidin-5-yl-methanol | CHEMBL29904
TypeSmall organic molecule
Emp. Form.C17H12Cl2N2O
Mol. Mass.331.196
SMILESOC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cncnc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a