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TargetAldose reductase (ALR2)
LigandBDBM50022396
Substrate/Competitorn/a
Meas. Tech.ChEBML_31633
IC50 1000±n/a nM
Citation Sarges, RSchnur, RCBelletire, JLPeterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem31:230-43 (1988) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (ALR2)
Name:Aldose reductase
Synonyms:Aldose reductase
Type:Protein
Mol. Mass.:35916.27
Organism:Bos taurus (Cattle)
Description:n/a
Residue:315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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BDBM50022396
NameBDBM50022396
Synonyms:7-trifluoromethylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione | CHEMBL81109
TypeSmall organic molecule
Emp. Form.C12H9F3N2O3
Mol. Mass.286.2067
SMILESFC(F)(F)c1ccc2c(OCCC22NC(=O)NC2=O)c1
Structure
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n/a