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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50019059
Substrate
n/a
Meas. Tech.
ChEMBL_33232 (CHEMBL873047)
Ki
16500±n/a nM
Citation
 Adejare, A; Gusovsky, F; Padgett, W; Creveling, CR; Daly, JW; Kirk, KL Syntheses and adrenergic activities of ring-fluorinated epinephrines. J Med Chem 31:1972-7 (1988) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50019059
Synonyms:
(+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol | 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol | 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol(2-FEPI) | CHEMBL43711
Type:
Small organic molecule
Emp. Form.:
C9H12FNO3
Mol. Mass.:
201.1949
SMILES:
CNCC(O)c1ccc(O)c(O)c1F
Structure:
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