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Target
Adenosine deaminase
Ligand
BDBM50011575
Substrate
n/a
Meas. Tech.
ChEBML_30977
Ki
6.30±n/a nM
Citation
 Cristalli, G; Franchetti, P; Grifantini, M; Vittori, S; Lupidi, G; Riva, F; Bordoni, T; Geroni, C; Verini, MA Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine. J Med Chem 31:390-3 (1988) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase
Type:
Enzyme
Mol. Mass.:
40759.44
Organism:
Homo sapiens (Human)
Description:
Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain.
Residue:
363
Sequence:
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
  
Inhibitor
Name:
BDBM50011575
Synonyms:
3-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-nonan-2-ol | CHEMBL18496
Type:
Small organic molecule
Emp. Form.:
C15H24N4O
Mol. Mass.:
276.3773
SMILES:
CCCCCCC(C(C)O)n1cnc2c(N)nccc12
Structure:
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