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TargetThymidylate synthase
LigandBDBM50023647
Substrate/Competitorn/a
Meas. Tech.ChEBML_209777
Ki 6800±n/a nM
Citation Chang, GSchwepler, DDecedue, CJBalzarini, JDe Clercq, EMertes, MP Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. J Med Chem31:1141-7 (1988) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase/GAR transformylase/AICAR transformylase
Synonyms:TS | TSase | Thymidylate synthase (TS)
Type:Enzyme
Mol. Mass.:35718.07
Organism:Homo sapiens (human)
Description:n/a
Residue:313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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  Blast E-value cutoff:
BDBM50023647
NameBDBM50023647
Synonyms:CHEMBL3144186 | Phosphoric acid mono-[5-(2,4-dioxo-5-phenyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester
TypeSmall organic molecule
Emp. Form.C15H17N2O8P
Mol. Mass.384.2778
SMILESO[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(-c2ccccc2)c(=O)[nH]c1=O |r|
Structure
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n/a