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Target
Adenosylhomocysteinase
Ligand
BDBM50019042
Substrate
n/a
Meas. Tech.
ChEBML_197369
IC50
80±n/a nM
Citation
 Madhavan, GV; McGee, DP; Rydzewski, RM; Boehme, R; Martin, JC; Prisbe, EJ Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem 31:1798-804 (1988) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50019042
Synonyms:
3-(6-Amino-purin-9-yl)-5-hydroxymethyl-4-methylene-cyclopentane-1,2-diol | CHEMBL53931
Type:
Small organic molecule
Emp. Form.:
C12H15N5O3
Mol. Mass.:
277.2792
SMILES:
Nc1ncnc2n(cnc12)C1C(O)C(O)C(CO)C1=C
Structure:
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