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Target
Neprilysin
Ligand
BDBM50034866
Substrate
n/a
Meas. Tech.
ChEMBL_64513 (CHEMBL677318)
IC50
18±n/a nM
Citation
 Ksander, GM; Diefenbacher, CG; Yuan, AM; Clark, F; Sakane, Y; Ghai, RD Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives. J Med Chem 32:2519-26 (1989) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rattus norvegicus (Rat)
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50034866
Synonyms:
2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-phenyl-pentanoic acid | CHEMBL47289
Type:
Small organic molecule
Emp. Form.:
C22H25NO5
Mol. Mass.:
383.4376
SMILES:
OC(=O)CCNC(=O)C(CC(Cc1ccccc1)C(O)=O)Cc1ccccc1
Structure:
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