Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50020500
Substrate
n/a
Meas. Tech.
ChEBML_152563
Ki
>2000000±n/a nM
Citation
 Ye, QH; Grunewald, GL Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase. J Med Chem 32:478-86 (1989) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50020500
Synonyms:
5-Methoxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine | CHEMBL434450
Type:
Small organic molecule
Emp. Form.:
C12H15NO
Mol. Mass.:
189.2536
SMILES:
COc1cccc2C3CC(CC3N)c12 |TLB:2:13:8:11.10,THB:12:11:6.13:8,5:6:8:11.10|
Structure:
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