Reaction Details Report a problem with these data
Target
Muscarinic receptor M1
Ligand
BDBM39341
Substrate
n/a
Meas. Tech.
ChEMBL_138128 (CHEMBL747250)
Ki
170±n/a nM
Citation
 Leader, H; Smejkal, RM; Payne, CS; Padilla, FN; Doctor, BP; Gordon, RK; Chiang, PK Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates. J Med Chem 32:1522-8 (1989) [PubMed]  Article 
Target
Name:
Muscarinic receptor M1
Synonyms:
Muscarinic acetylcholine receptor M1
Type:
PROTEIN
Mol. Mass.:
15022.43
Organism:
Bos taurus
Description:
ChEMBL_140161
Residue:
139
Sequence:
ETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRTPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPAKQPPRSSPNTVKRPTRKGRERAGKGQKPRGKEQLAKR
  
Inhibitor
Name:
BDBM39341
Synonyms:
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | 11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride | 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride | 11-[2-(4-methylpiperazin-1-yl)ethanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride | 11-[2-(4-methylpiperazino)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride | CHEMBL9967 | MLS000069702 | PIRENZEPINE | PIRENZEPINE DIHYDROCHLORIDE | SMR000058502 | cid_185248
Type:
Small organic molecule
Emp. Form.:
C19H21N5O2
Mol. Mass.:
351.4023
SMILES:
CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Structure:
Search PDB for entries with ligand similarity: