Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM50013116
Substrate
n/a
Meas. Tech.
ChEMBL_208195 (CHEMBL819098)
Ki
>1000000±n/a nM
Citation
 Palomino, E; Meltsner, BR; Kessel, D; Horwitz, JP Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. J Med Chem 33:258-63 (1990) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50013116
Synonyms:
Benzoic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (ddUrd) | CHEMBL88993
Type:
Small organic molecule
Emp. Form.:
C16H16N2O5
Mol. Mass.:
316.3086
SMILES:
O=C(OC[C@@H]1CC[C@@H](O1)n1ccc(=O)[nH]c1=O)c1ccccc1
Structure:
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