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Target
Thymidine kinase, cytosolic
Ligand
BDBM50013118
Substrate
n/a
Meas. Tech.
ChEMBL_208193 (CHEMBL819096)
Ki
1690000±n/a nM
Citation
 Palomino, E; Meltsner, BR; Kessel, D; Horwitz, JP Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. J Med Chem 33:258-63 (1990) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50013118
Synonyms:
1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one (ddeUrdS) | CHEMBL86455
Type:
Small organic molecule
Emp. Form.:
C9H10N2O3S
Mol. Mass.:
226.252
SMILES:
OC[C@H]1O[C@H](C=C1)n1ccc(=S)[nH]c1=O |c:5|
Structure:
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