Reaction Details Report a problem with these data
Target
Aromatase
Ligand
BDBM50014757
Substrate
n/a
Meas. Tech.
ChEBML_51212
EC50
>2000±n/a nM
Citation
 Jones, CD; Winter, MA; Hirsch, KS; Stamm, N; Taylor, HM; Holden, HE; Davenport, JD; Krumkalns, EV; Suhr, RG Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups. J Med Chem 33:416-29 (1990) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50014757
Synonyms:
(4-Chloro-phenyl)-(2-chloro-phenyl)-pyridin-3-yl-methanol : (Hydrochloride) | CHEMBL137192
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2NO
Mol. Mass.:
330.208
SMILES:
OC(c1ccc(Cl)cc1)(c1cccnc1)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: