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Target
Aromatase
Ligand
BDBM50014315
Substrate
n/a
Meas. Tech.
ChEMBL_51210 (CHEMBL664329)
IC50
3±n/a nM
Citation
 Cole, PA; Robinson, CH Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem 33:2933-42 (1990) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50014315
Synonyms:
(rac)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1-methyl-1H-benzo[d][1,2,3]triazole | 6-[(4-Chloro-phenyl)-[1,2,4]triazol-1-yl-methyl]-1-methyl-1H-benzotriazole | CHEMBL100749 | Vorozole
Type:
Small organic molecule
Emp. Form.:
C16H13ClN6
Mol. Mass.:
324.768
SMILES:
Cn1nnc2ccc(cc12)C(c1ccc(Cl)cc1)n1cncn1
Structure:
Search PDB for entries with ligand similarity: