Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50015234
Substrate
n/a
Meas. Tech.
ChEBML_213083
Ki
2700±n/a nM
Citation
 Tidwell, RR; Jones, SK; Geratz, JD; Ohemeng, KA; Cory, M; Hall, JE Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J Med Chem 33:1252-7 (1990) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50015234
Synonyms:
4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE | 4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine | 4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine | 4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine | CHEMBL25105 | Hexamidine | US9138393, Hexamidine diisethionate | US9144538, Hexamidine diisethionate
Type:
Small organic molecule
Emp. Form.:
C20H26N4O2
Mol. Mass.:
354.446
SMILES:
NC(=N)c1ccc(OCCCCCCOc2ccc(cc2)C(N)=N)cc1
Structure:
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