Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50014034
Substrate
n/a
Meas. Tech.
ChEBML_195777
pH
6±n/a
IC50
3.6±n/a nM
Comments
extracted
Citation
 Thaisrivongs, S; Mao, B; Pals, DT; Turner, SR; Kroll, LT Renin inhibitory peptides. A beta-aspartyl residue as a replacement for the histidyl residue at the P-2 site. J Med Chem 33:1337-43 (1990) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50014034
Synonyms:
3-[1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-(2-methyl-butylcarbamoyl)-hexylcarbamoyl]-2-hydroxy-4-oxo-5-phenoxy-pentanoic acid | CHEMBL442105
Type:
Small organic molecule
Emp. Form.:
C32H50N2O8
Mol. Mass.:
590.748
SMILES:
CC[C@@H](C)CNC(=O)[C@@H](CC(O)[C@H](CC1CCCCC1)NC(=O)C(C(O)C(O)=O)C(=O)COc1ccccc1)C(C)C
Structure:
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