Reaction Details Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50007910
Substrate
n/a
Meas. Tech.
ChEBML_195055
IC50
7900±n/a nM
Citation
 Jie, L; Van Aerschot, A; Balzarini, J; Janssen, G; Busson, R; Hoogmartens, J; De Clercq, E; Herdewijn, P 5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity. J Med Chem 33:2481-7 (1990) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50007910
Synonyms:
CHEMBL3350644 | beta,gama-methylene AzddTPP
Type:
Small organic molecule
Emp. Form.:
C12H20N5O13P3
Mol. Mass.:
535.2342
SMILES:
CC1N([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COCP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC(=O)C1=C
Structure:
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