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Target
Dihydrofolate reductase
Ligand
BDBM50010934
Substrate
n/a
Meas. Tech.
ChEBML_54214
IC50
>20000±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Moran, RG; Freisheim, JH Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate. J Med Chem 34:227-34 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50010934
Synonyms:
2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid | CHEMBL419087
Type:
Small organic molecule
Emp. Form.:
C21H23N7O5
Mol. Mass.:
453.4512
SMILES:
CN(Cc1cnc2nc(C)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure:
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