Reaction Details Report a problem with these data
Target
Sodium-dependent dopamine transporter
Ligand
BDBM50011395
Substrate
n/a
Meas. Tech.
ChEBML_49348
IC50
2070±n/a nM
Citation
Kline, RH; Wright, J; Eshleman, AJ; Fox, KM; Eldefrawi, ME Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. J Med Chem 34:702-5 (1991) [PubMed] Article
More Info.:
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
Dopamine transporter | SC6A3_BOVIN | SLC6A3 | Sodium-dependent dopamine transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75707.43
Organism:
BOVINE
Description:
Dopamine Transporter SLC6A3 BOVINE::P27922
Residue:
693
Sequence:
MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDRETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELALGQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHCNHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSCLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFHRLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSAMGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATFRPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGRVDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPPVPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
Inhibitor
Name:
BDBM50011395
Synonyms:
3-(3-Amino-phenylcarbamoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL350155
Type:
Small organic molecule
Emp. Form.:
C17H23N3O4
Mol. Mass.:
333.3822
SMILES:
COC(=O)C1C2CC[C@H](C[C@@H]1OC(=O)Nc1cccc(N)c1)N2C |TLB:23:22:4.10.9:6.7,11:10:22:6.7,THB:2:4:22:6.7|